Key questions about Melatonin, the sleep hormone

One of the key ingredients in BIOTONE’s new Lab+Blends CBD Dream Drops, a drug-free, non-habit forming sleep aid, is Melatonin. No doubt you’ve heard of Melatonin. It’s a hormone that is used as a sleep aid, often recommended for long flights to alleviate jet lag. But you or your clients may still have questions on how it works to help you go to sleep and have better quality sleep. Following are answers to some of the key questions about Melatonin.

What is it?

Melatonin is a natural hormone that primarily is produced by pineal gland, which is located in the brain. (The pineal gland got its name from its pine-cone like shape.) Melatonin regulates the body’s sleep-wake cycle, which is why it’s often call the “sleep hormone.”

How is it released in the body?

Your body’s internal clock, which is also known as the circadian rhythm, affects how much melatonin the pineal gland produces. When it begins to get dark, melatonin levels begin to increase and stay high to let you know it’s time to go to sleep.  Conversely, light suppresses the production of Melatonin. So when the sun rises, melatonin levels decrease, letting your body know that it’s time to wake up.

What does science say about Melatonin?

As we age, melatonin production declines and the occurrence of sleep disorders increases. A study conducted in 2007, by CPS Research, Glasgow, UK, included 354 males and females aged 55 to 80. Of these, 177 received prolonged-release Melatonin and 177 a placebo.

Primary care physicians conducted the study, which consisted of a 2-week, single blind placebo run-in period followed by a 3-week double blind treatment period with prolonged-release melatonin or placebo. Study participants received one tablet per day at 2 hours before bedtime. The researchers found that the prolonged-release melatonin resulted in significant and clinically meaningful improvements in sleep quality, morning alertness, sleep onset latency and quality of life in primary insomnia patients aged 55 years and over.1

How much Melatonin is effective?

As little at 1 MG would work. 2

Are there side effects of Melatonin?

Melatonin is considered safe for short term use. Side effects are uncommon but can include drowsiness, headache, dizziness or nausea. 3

About Lab+Blends CBD Dream Drops

BIOTONE’s revolutionary new offering features Cannabidiol (CBD), Melatonin and Vitamin B6, a powerful trio of ingredients proven to enhance sleep quality.

Known for its anxiety-reducing benefits, THC-free CBD Extract, derived from industrial hemp, is calming and relaxing with no psychoactive effects.  It sets the stage for deep, restful sleep by increasing overall sleep quality and time spent sleeping.  By combining CBD with Melatonin, the hormone that tells the body when it’s time to go to sleep, and Vitamin B6, which helps regulate the levels of Melatonin, Dream Drops helps give your body the rest it requires without the foggy feeling often associated with deep sleep.

In addition to its sleep-enhancing and pain-reducing ingredients, Dream Drops features an innovative water-based delivery system that maximizes absorption. It helps users fall asleep faster, stay asleep longer and wake up rested and ready to meet the day.

Key References:

1. “Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes, 2017, Sleep Med Review, NCBI Resources,

2. “Rest easy: MIT study confirms melatonin's value as sleep aid,” March 1, 2015, MIT News On Campus and Around The World

3.  Melatonin, In Depth, NIH, National Center for Complementary and Integrative Health

Other sources:

“How  Melatonin Can Help You Sleep and Feel Better, Healthline

ea“Melatonin for Sleep: Does it Work?” Health, John Hopkins Medicine,

 “The Pineal Gland and Melatonin,” November, 2018, VIVO Pathophysiology Colorado State


Torborg, “Mayo Clinic Q and A: Melatonin may help you sleep,” July 22, 2017, Mayo Clinic News Network

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